Question

Essay and Thesis Writing

Tue Jan 14, 2020 6:43 pm

What is fibrinogen?

Source: Bovine plasma

Asked by Lisa Clara

uThink Member

3 answers

Tue Jan 14, 2020 6:44 pm

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
For more information: https://www.creative-enzymes.com/produc ... _4211.html

Lisa Clara

uThink Member

Thu Jan 16, 2020 4:50 pm

thank you, it is very interesting

LindaWu

uThink Member

Wed Oct 07, 2020 5:19 pm

I recommend that you contact only professionals.

sheylaphillips

uThink Member


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